Etiology, seasonality, and clinical characterization of viral respiratory infections among hospitalized children in Beirut, Lebanon
Identifieur interne : 001145 ( Main/Exploration ); précédent : 001144; suivant : 001146Etiology, seasonality, and clinical characterization of viral respiratory infections among hospitalized children in Beirut, Lebanon
Auteurs : Mayda Finianos [Liban] ; Randi Issa [Liban] ; Martin D. Curran [Royaume-Uni] ; Claude Afif [Liban] ; Maryam Rajab [Liban] ; Jihad Irani [Liban] ; Noha Hakimeh [Liban] ; Amal Naous [Liban] ; Marie-Joelle Hajj [Liban] ; Pierre Hajj [Liban] ; Tamima El Jisr [Liban] ; Mira El Chaar [Liban]Source :
- Journal of Medical Virology [ 0146-6615 ] ; 2016-11.
Abstract
Acute respiratory tract viral infections occur worldwide and are one of the major global burdens of diseases in children. The aim of this study was to determine the viral etiology of respiratory infections in hospitalized children, to understand the viral seasonality in a major Lebanese hospital, and to correlate disease severity and the presence of virus. Over a 1‐year period, nasal and throat swabs were collected from 236 pediatric patients, aged 16‐year old or less and hospitalized for acute respiratory illness. Samples collected were tested for the presence of 17 respiratory viruses using multiplex real‐time RT‐PCR. Pathogens were identified in 165 children (70%) and were frequently observed during fall and winter seasons. Co‐infection was found in 37% of positive samples. The most frequently detected pathogens were human Rhinovirus (hRV, 23%), Respiratory Syncytial Virus (RSV, 19%), human Bocavirus (hBov, 15%), human Metapneumovirus (hMPV, 10%), and human Adenovirus (hAdV, 10%). A total of 48% of children were diagnosed with bronchiolitis and 25% with pneumonia. While bronchiolitis was often caused by RSV single virus infection and hAdV/hBoV coinfection, pneumonia was significantly associated with hBoV and HP1V1 infections. No significant correlation was observed between a single viral etiology infection and a specific clinical symptom. This study provides relevant facts on the circulatory pattern of respiratory viruses in Lebanon and the importance of using PCR as a useful tool for virus detection. Early diagnosis at the initial time of hospitalization may reduce the spread of the viruses in pediatric units. J. Med. Virol. 88:1874–1881, 2016. © 2016 Wiley Periodicals, Inc.
Url:
DOI: 10.1002/jmv.24544
Affiliations:
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The aim of this study was to determine the viral etiology of respiratory infections in hospitalized children, to understand the viral seasonality in a major Lebanese hospital, and to correlate disease severity and the presence of virus. Over a 1‐year period, nasal and throat swabs were collected from 236 pediatric patients, aged 16‐year old or less and hospitalized for acute respiratory illness. Samples collected were tested for the presence of 17 respiratory viruses using multiplex real‐time RT‐PCR. Pathogens were identified in 165 children (70%) and were frequently observed during fall and winter seasons. Co‐infection was found in 37% of positive samples. The most frequently detected pathogens were human Rhinovirus (hRV, 23%), Respiratory Syncytial Virus (RSV, 19%), human Bocavirus (hBov, 15%), human Metapneumovirus (hMPV, 10%), and human Adenovirus (hAdV, 10%). A total of 48% of children were diagnosed with bronchiolitis and 25% with pneumonia. While bronchiolitis was often caused by RSV single virus infection and hAdV/hBoV coinfection, pneumonia was significantly associated with hBoV and HP1V1 infections. No significant correlation was observed between a single viral etiology infection and a specific clinical symptom. This study provides relevant facts on the circulatory pattern of respiratory viruses in Lebanon and the importance of using PCR as a useful tool for virus detection. Early diagnosis at the initial time of hospitalization may reduce the spread of the viruses in pediatric units. J. Med. Virol. 88:1874–1881, 2016. © 2016 Wiley Periodicals, Inc.</div></front></TEI><affiliations><list><country><li>Liban</li><li>Royaume-Uni</li></country></list><tree><country name="Liban"><noRegion><name sortKey="Finianos, Mayda" sort="Finianos, Mayda" uniqKey="Finianos M" first="Mayda" last="Finianos">Mayda Finianos</name></noRegion><name sortKey="Afif, Claude" sort="Afif, Claude" uniqKey="Afif C" first="Claude" last="Afif">Claude Afif</name><name sortKey="El Chaar, Mira" sort="El Chaar, Mira" uniqKey="El Chaar M" first="Mira" last="El Chaar">Mira El Chaar</name><name sortKey="El Chaar, Mira" sort="El Chaar, Mira" uniqKey="El Chaar M" first="Mira" last="El Chaar">Mira El Chaar</name><name sortKey="El Jisr, Tamima" sort="El Jisr, Tamima" uniqKey="El Jisr T" first="Tamima" last="El Jisr">Tamima El Jisr</name><name sortKey="Hajj, Marie Oelle" sort="Hajj, Marie Oelle" uniqKey="Hajj M" first="Marie-Joelle" last="Hajj">Marie-Joelle Hajj</name><name sortKey="Hajj, Pierre" sort="Hajj, Pierre" uniqKey="Hajj P" first="Pierre" last="Hajj">Pierre Hajj</name><name sortKey="Hakimeh, Noha" sort="Hakimeh, Noha" uniqKey="Hakimeh N" first="Noha" last="Hakimeh">Noha Hakimeh</name><name sortKey="Irani, Jihad" sort="Irani, Jihad" uniqKey="Irani J" first="Jihad" last="Irani">Jihad Irani</name><name sortKey="Issa, Randi" sort="Issa, Randi" uniqKey="Issa R" first="Randi" last="Issa">Randi Issa</name><name sortKey="Naous, Amal" sort="Naous, Amal" uniqKey="Naous A" first="Amal" last="Naous">Amal Naous</name><name sortKey="Rajab, Maryam" sort="Rajab, Maryam" uniqKey="Rajab M" first="Maryam" last="Rajab">Maryam Rajab</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Curran, Martin D" sort="Curran, Martin D" uniqKey="Curran M" first="Martin D." last="Curran">Martin D. 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